Driving Time from Des Moines to St. Louis
Driving from Des Moines to St. Louis is about 333 mi and takes roughly 5 hr 58 min. See the fuel-cost estimate, distance and route tips.
Des Moines and St. Louis are about 273 mi (440 km) apart in a straight line. By road that works out to roughly 333 mi (536 km), a drive of about 5 hr 58 min. A nonstop flight covers the great-circle distance in approximately 1 hr.
| Straight-line distance | 273 mi / 440 km |
| Road distance (est.) | 333 mi / 536 km |
| Driving time (est.) | 5 hr 58 min |
| Nonstop flight (est.) | 1 hr |
| Driving fuel (est., 1-way) | $42 |
| Typical flight fare | $80–$250 |
| Geographic midpoint | 40.126, -91.866 |
How these estimates work
Straight-line distance uses the haversine formula on each city's coordinates. Road distance applies a circuity factor (~1.2–1.4×) and driving time a blended average speed. Flight time uses typical jet cruise speed plus ~30 minutes for taxi, climb and descent. Treat all figures as planning estimates.
Frequently asked questions
Des Moines to St. Louis is about 273 mi (440 km) in a straight line, and roughly 333 mi (536 km) by road.