Los Angeles to Phoenix crosses the Sonoran Desert on I-10 east — about 370 miles of wide-open Southwestern highway. The landscape shifts from LA sprawl through Palm Springs and the Coachella Valley, then into striking desert as you enter Arizona.
This is quintessential American road-trip territory: saguaro cacti, dramatic rock formations, and roadside kitsch. The drive is long but beautiful, especially in the late afternoon light.
Stops Along the Way
An iconic desert resort city about 2 hours from LA — great for a break, with mid-century architecture, hiking, and the Palm Springs Aerial Tramway.
A unique desert town famous for its gem and mineral shows — one of the quirkiest road trip stops in America.
Tips for This Trip
Summer heat is extreme
July and August temperatures routinely exceed 110°F (43°C) in the Sonoran Desert. Check your car's cooling system and carry extra water.
I-10 east of Indio gets scenic fast
Once you clear the Coachella Valley, the drive becomes genuinely beautiful with boulder-strewn desert and mountain ranges.
Strong tail winds are common heading east
The prevailing westerlies give you better fuel economy heading LA→Phoenix than the reverse — a nice bonus on a long drive.
🏨 Hotels in Phoenix
Compare 2M+ properties on Booking.com — free cancellation on most stays. Filter by price, neighborhood, and traveler ratings.
Search Hotels in Phoenix →Affiliate link — we may earn a small commission at no extra cost to you.
Frequently Asked Questions
Phoenix is about 300 miles (483 km) from Los Angeles in a straight line, and approximately 370 miles (595 km) by road via Interstate 10 through the Sonoran Desert.