Miami to Tampa crosses the width of the Florida peninsula — about 280 miles via the most direct route. Two options exist: the faster I-75 "Alligator Alley" through the Everglades to Fort Myers, or the slightly longer route via Orlando and I-4.
Alligator Alley (I-75) is the preferred route for speed, cutting directly across South Florida with the Everglades on both sides. The Naples and Fort Myers area makes a natural stop.
Stops Along the Way
An upscale Gulf Coast city with beautiful beaches, about halfway on the Alligator Alley route. Excellent for lunch.
Beach city on Florida's Gulf Coast — worth a stop or even an overnight break if you're not rushing to Tampa.
Tips for This Trip
Alligator Alley is scenic but remote
I-75 through the Everglades has limited services for 80+ miles — make sure you're fueled up and have water before entering.
The I-75/I-4 combination via Orlando adds 30 minutes
Going via Orlando adds distance but provides more service stops and links to the theme park area if that's relevant.
Arrive at the Sunshine Skyway in daylight
The iconic Sunshine Skyway Bridge approach to Tampa is beautiful — timing your arrival for late afternoon gives stunning light over Tampa Bay.
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Frequently Asked Questions
Tampa is about 210 miles (338 km) from Miami in a straight line, and roughly 280 miles (450 km) by road via I-75 (Alligator Alley) through Naples and Fort Myers.