The drive from Miami to Key West along the Overseas Highway is one of America's most distinctive road trips — 113 miles of road that hops across 42 bridges and a string of tropical islands, with the turquoise Atlantic on one side and the Gulf of Mexico on the other. It's a journey that feels like driving across the sea itself.
This guide covers the route down the Keys, the best stops for snorkelling, seafood, and sunsets, and how to make the most of this laid-back tropical drive.
The Route & How Long to Spend
The Overseas Highway (US-1) runs about 113 miles from the mainland to Key West, marked by green Mile Markers (MM) counting down to zero at Key West. The pure drive is only about 3.5 hours, but the Keys reward slowing down — three to four days lets you snorkel, explore, and soak up the islands' unhurried rhythm.
Best Stops Down the Keys
The "Diving Capital of the World" and home to John Pennekamp Coral Reef State Park, the first underwater park in the US.
The "Sport Fishing Capital," with great seafood, art galleries, and the famous tarpon feeding at Robbie's Marina.
Home to the Turtle Hospital and the iconic Seven Mile Bridge — the most dramatic stretch of the drive.
Arguably the best beach in the Keys, with pale sand and clear water.
The vibrant end of the road — Duval Street, the Hemingway Home, the southernmost point marker, and the nightly sunset celebration at Mallory Square.
When to Go
The best time is the dry season from December to April, with sunny, warm, low-humidity weather — though it's also peak season for crowds and prices. Summer is hot, humid, and falls within hurricane season (June–November), but brings lower prices and good diving conditions on calm days.
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Tips
- Book accommodation well ahead in peak season — the Keys have limited rooms and they sell out.
- Use the Mile Markers (MM) for navigation; locals give directions by them.
- Pack reef-safe sunscreen — it's required in some areas to protect the coral.
- Plan to be in Key West for sunset at Mallory Square at least once.
Frequently Asked Questions
The drive along the Overseas Highway is about 165 miles from Miami and takes roughly 3.5 hours without stops. However, the Keys are best enjoyed over three to four days to allow time for snorkelling, beaches, and the islands' relaxed pace.